Zheng-Ming Ding, Ph.D.
Zheng-Ming Ding, Ph.D.
Assistant Research Professor
|Personal Statement||Alcohol use disorders (AUDs) are among the most prevalent psychiatric diseases around the world. In addition, alcohol drinking is frequently correlated with high rates of tobacco smoking. Despite extensive research over several decades, the neurobiology of alcohol abuse and alcohol-nicotine poly-drug abuse remains incompletely understood and there is strong demand for effective pharmacological therapeutics. Thus, my research has been focused on studying neurobiological mechanisms involved in these disorders using animal models.|
Undergraduate: Jiangxi College of Chinese Medicine
Postdoctoral: Indiana University
|Current Academic Interests||Teaching: involved in teaching of graduate students from school of medicine and training of medical students on laboratory skills
Research: On-going studies in my lab are characterizing: a) neuro-anatomical sites and circuits underlying the reinforcing and rewarding effects of drugs of abuse; b) neurochemical substrates that may contribute to the maintenance of and relapse to alcohol and poly-drug abuse.
Ding ZM, Oster SM, Hall SR, Engleman EA, Hauser SR, McBride WJ, Rodd RA (2011) The stimulating effects of ethanol on ventral tegmental area dopamine neurons projecting to the ventral pallidum and medial prefrontal cortex in female Wistar rats: regional difference and involvement of serotonin-3 receptors. Psychopharmacology 216: 245-255.
Ding ZM, Katner SN, Rodd ZA, Truitt WA, Sheketha HR, Deehan GA Jr, Engleman EA, McBride WJ (2012) Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol. 46: 217-223.
Ding ZM, Rodd ZA, Engleman EA, Bailey JA, Lahiri DL, McBride WJ (2013) Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. Addict Biol. 18: 297-306.
Ding ZM, Ingraham CM, Rodd ZA, McBride WJ (2015) The reinforcing effects of ethanol within the posterior ventral tegmental area depend upon dopamine neurotransmission to forebrain cortico-limbic systems. Addict Biol. In press